Highlights:
- AEROPATH (www.aeropath.eu ) is an ambitious multidisciplinary research programme designed to support early stage antimicrobial drug development.
- The project aims to advance understanding, at the molecular level, of fundamental and important aspects of the biology of Gram-negative bacteria targeting in particular the important pathogen Pseudomonas aeruginosa. Modern technologies in chemo-bioinformatics, proteomics, molecular and structural biology, computational chemistry and screening technologies will be exploited to identify ligands and inhibitors (hit and lead compounds) with the potential to drive the discovery of improved therapies for Gram-negative infections.
- We are currently looking for a highly motivated computational chemist to be part of a multi-disciplinary team to apply molecular modeling methods towards the discovery and optimization of inhibitors of key enzymes of gram-Negative pathogens.
- The post is available immediately until 31/10/2012. The level of appointment is flexible and will depend on experience and track record. Training, as required will be provided in a supportive environment enabling researchers to extend their skills and expertise. Career progression is important and staff will be encouraged to participate in a wide range of research, and in this the ability to work well in a team will be critical. The successful candidate will benefit from access to cutting edge facilities in computationally chemistry, crystallography, biochemistry, synthetic and medicinal chemistry, and drug discovery.
- Your responsibilities:
- Target assessment
- Virtual screening
- Structure- and ligand-based molecular design
- HTS data analysis
- ADMET and physicochemical property prediction
6. Your qualifications:
- PhD in Computational Chemistry or in Medicinal/Synthetic Chemistry or
X-ray Crystallography with experience in molecular modelling
- Sound understanding of the physical chemical properties of small-molecules and their interactions with proteins
- Experience with structure- and ligand-based molecular design
- Strong interpersonal, communication and presentation skills
- Scripting skills (e.g. Python) and a working knowledge of a workflow programme are highly desirable
7. Informal enquiries may be made to Dr Ruth Brenk, tel: (01382) 386230 or e-mail: r.brenk@dundee.ac.uk (Applications sent to this address will not be considered).
A few facts about The College of Life Sciences at Dundee :
- The College of Life Sciences
from 54 countries and an annual research turnover in excess of 20 million.
- According to Thompson Scientific of Philadelphia, based on citations per paper over the last 10 years, Dundee is the top University in Europe in Biology and Biochemistry and 2nd in Europe in Molecular Biology and Genetics.
- Dundee has twice been named the best place to work in Europe in a poll of scientists conducted by The Scientist magazine.
- The College of Life Sciences has been consistently rated 5-star (the highest rating) by the UK
In addition to an excellent scientific environment, Tayside offers an affordable standard of living in an area of outstanding natural beauty situated beside the sea and the highlands of Scotland
Applications in the form of a CV and covering letter, including the names and addresses of 3 referees, should be sent to HR-LifeSciences+*+dundee.ac.uk quoting LS/3198.
Alternatively, please send 2 hard copies of your CV and covering letter to Human Resources, College of Life Sciences , MSI/WTB/JBC Complex, University of Dundee , DD1 5EH
Applicants will only be contacted if invited for interview.
Closing Date: 7 April 2010
The University of Dundee
The University of Dundee
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